Axis Labs BCAA Ethyl Ester, 180 Cap

BCAA Ethyl Ester (BCAAE2™) Ester-Sorb™ Technology

Axis Labs® introduces BCAA Ethyl Ester (BCAAE2™); an anti-catabolic powerhouse. Axis Labs® BCAAE2™ is a high potency formula containing the essential amino acids L-Leucine, L-Valine and L-Isoleucine in a revolutionary ethyl ester form and in a specific ratio to maximize their effectiveness. These three protein sparing amino acids are known as branched chain amino acids, and play important roles in protein synthesis and energy metabolism. Your body can not manufacture its own branch chain amino acids, so they must be supplied through your diet. Studies have shown that they are important for a variety of reasons including muscle growth and recuperation. BCAAE2™ is truly at the forefront of biochemically engineered supplements.

BCAA Ethyl Ester (BCAAE2™) Highlights:
• Dramatically more Potent than Regular BCAA's
• Unmatched BCAA Absorption and Utilization
• Potent Anabolic Activity to Increase Muscle Growth
    - Increased Protein Synthesis and Nitrogen Retention
    - Maintain Positive Nitrogen Balance Between Meals
• Potent Anti-Catabolic Activity to Inhibit Muscle Breakdown
    - Muscle sparing
    - Glycogen sparing
• Improved and Increased Muscle Recovery
    - Lower lactate production
• Specific 2:1:1 BCAA Ratio to Significantly Improve Effects

Branched Chain Amino Acids (BCAAs) function by increasing protein synthesis and nitrogen retention. Athletes and bodybuilders recognize that protein synthesis and nitrogen retention are important anabolic functions required for muscle growth. Axis Labs® BCAAE2™ help fuel muscle growth and are dramatically more potent than regular Branch Chain Amino Acids. But the important benefits of BCAAE2™ aren’t limited to muscle growth. They can also aid in recuperation by decreasing lactic acid levels in muscle cells. Branch Chain Amino Acids can also aide in recuperation by increasing muscle glycogen concentration to a greater degree than carbohydrates alone. Additionally, BCAAs have a glycogen sparing effect during exercise. This is a great benefit, and can an athlete reach new levels of intensity. Because of their anticatabolic effect BCAAs may also help during extreme dieting by preventing muscle tissue breakdown.

Axis Labs® BCAAE2™ are an amazing advance in scientific supplement technology, that are much more effective than traditional BCAA supplements. The ethyl ester technology we use allows the BCAAs to be much more bioavailable. They are not broken down by the body as quickly as normal amino acids and they can enter the blood stream from the GI tract more readily.

Limited absorption through the digestive tract has plagued other BCAA products since they were first released. Regular BCAAs are degraded rapidly, leaving small amounts of the original dose active. Because of the rapid breakdown of BCAAs, their ability to promote muscle growth is limited. The limited potential of BCAAs has historically been a problem, until now.

The reason BCAAE2™ is much more effective than other BCAA products is because of the ethyl ester added to each BCAA molecule. In fact, BCAAE2™ utilizes the same ethyl ester delivery technology that makes our NE2™ many times more effective than regular L-Arginine. The ethyl ester makes the BCAA’s less polar and therefore more easily absorbed in the digestive tract. Because of this design, each amino acid can pass through the intestine largely intact. The ethyl ester also protects the BCAA molecules from rapid degradation, making them much more effective in smaller doses than other BCAA products. BCAAE2™ is superior in design to all other current BCAA products on the market and after one week of use, you will never train without them again. BCAAE2™ provides a much more effective and efficient way to experience the benefits of BCAA supplementation. If you are ready to take training to the next level and record muscle growth, then you are ready for BCAAE2™.

Demand more from your BCAA's. Demand Axis Labs® BCAA Ethyl Ester!

Other Ingredients: Magnesium stearate, gelatin.

Directions: As a dietary supplement, take 2 to 4 capsules 1 to 3 times daily, preferably prior to and after exercise and/or with meals.

Store in a cool place. Protect from heat, light and moisture.

WARNING: KEEP OUT OF REACH OF CHILDREN. This product is not intended for anyone under the age of 16. Consult your physician before using any dietary supplement. Do not take this product if you have any medical condition and/or are taking any prescription medication(s). Discontinue use if experiencing any adverse side effects.

Manufactured with pride in the USA.
BCAAE2™ and Ester-Sorb™ registered trademark of Axis Labs®.

* These statements have not been evaluated by the FDA. This product is not intended to diagnose, treat, cure or prevent any disease.

References:
1) Anthony JC, Anthony TG, Layman DK. Leucine supplementation enhances skeletal muscle recovery in rats following exercise. J Nutr. 1999 Jun;129(6):1102-6.

2) Bassit RA, Sawada LA, Bacurau RF, Navarro F, Costa Rosa LF. The effect of BCAA supplementation upon the immune response of triathletes. Med Sci Sports Exerc. 2000 Jul;32(7):1214-9.

3) Bigard AX, Lavier P, Ullmann L, Legrand H, Douce P, Guezennec CY. Branched-chain amino acid supplementation during repeated prolonged skiing exercises at altitude. Int J Sport Nutr 1996 Sep;6(3):295-306.

4) Blomstrand E, Andersson S, Hassmen P, Ekblom B, Newsholme EA. Effect of branched-chain amino acid and carbohydrate supplementation on the exercise-induced change in plasma and muscle concentration of amino acids in human subjects. Acta Physiol Scand. 1995 Feb;153(2):87-96.

5) Blomstrand E, Ek S, Newsholme EA. Influence of ingesting a solution of branched-chain amino acids on plasma and muscle concentrations of amino acids during prolonged submaximal exercise. Nutrition. 1996 Jul-Aug;12(7-8):485-90.

6) Blomstrand E, Hassmen P, Ekblom B, Newsholme EA. Administration of branched-chain amino acids during sustained exercise--effects on performance and on plasma concentration of some amino acids. Eur J Appl Physiol Occup Physiol. 1991;63(2):83-8.

7) De Palo EF, Gatti R, Cappellin E, Schiraldi C, De Palo CB, Spinella P. Plasma lactate, GH and GH-binding protein levels in exercise following BCAA supplementation in athletes. Amino Acids. 2001;20(1):1-11.

8) Galassetti, P., Gibbons, F., Hamilton, K., Lacy, D., Cherrington, A., Wasserman, D. Enhanced muscle glucose uptake facilitates nitrogen efflux from exercised muscle. J Appl Physiol. June 1, 1998; 84(6): 1952 - 1959.

9) Gijsman HJ, Scarna A, Harmer CJ, McTavish SB, Odontiadis J, Cowen PJ, Goodwin GM. A dose-finding study on the effects of branch chain amino acids on surrogate markers of brain dopamine function. Psychopharmacology (Berl). 2002 Mar;160(2):192-7. Epub 202 Jan 10.

10) Hargreaves MH, Snow R. Amino acids and endurance exercise. Int J Sport Nutr Exerc Metab. 2001 Mar;11(1):133-45.

11) Layman DK. The role of leucine in weight loss diets and glucose homeostasis. J Nutr. 2003 Jan;133(1):261S-267S.

12) Lemon PW. Beyond the zone: protein needs of active individuals. J Am Coll Nutr. 2000 Oct;19(5 Suppl):513S-521S.

13) MacLean DA, Graham TE, Saltin B. Branched-chain amino acids augment ammonia metabolism while attenuating protein breakdown during exercise. Am J Physiol. 1994 Dec;267(6 Pt 1):E1010-22.

14) Mero A, Pitkanen H, Oja SS, Komi PV, Pontinen P, Takala T. Leucine supplementation and serum amino acids, testosterone, cortisol and growth hormone in male power athletes during training. J Sports Med Phys Fitness 1997 Jun;37(2):137-45.

15) Mero A. Leucine supplementation and intensive training. Sports Med. 1999 Jun;27(6):347-58.

16) Mittleman KD, Ricci MR, Bailey SP. Branched-chain amino acids prolong exercise during heat stress in men and women. Med Sci Sports Exerc. 1998 Jan;30(1):83-91.

17) Mourier A, Bigard AX, de Kerviler E, Roger B, Legrand H, Guezennec CY. Combined effects of caloric restriction and branched-chain amino acid supplementation on body composition and exercise performance in elite wrestlers. Int J Sports Med. 1997 Jan;18(1):47-55.

18) Platell C, Kong SE, McCauley R, Hall JC. Branched-chain amino acids. J Gastroenterol Hepatol. 2000 Jul;15(7):706-17.

19) Riazi R, Wykes LJ, Ball RO, Pencharz PB. The total branched-chain amino acid requirement in young healthy adult men determined by indicator amino acid oxidation by use of L-[1-13C]phenylalanine. J Nutr. 2003 May;133(5):1383-9.

20) Shimomura Y, Murakami T, Nakai N, Nagasaki M, Obayashi M, Li Z, Xu M, Sato Y, Kato T, Shimomura N, Fujitsuka N, Tanaka K, Sato M. Suppression of glycogen consumption during acute exercise by dietary branched-chain amino acids in rats. J Nutr Sci Vitaminol (Tokyo). 2000 Apr;46(2):71-7.

21) Silk DB, Hegarty JE, Fairclough PD, Clark ML. Characterization and nutritional significance of peptide transport in man. Ann Nutr Metab. 1982;26(6):337-52.

22) Snow, R., Carey, M., Stathis, C., Febbraio, M., Hargreaves, M. Effect of carbohydrate ingestion on ammonia metabolism during exercise in humans.
J Appl Physiol. May 1, 2000; 88(5): 1576 - 1580.

23) Stein TP, Donaldson MR, Leskiw MJ, Schluter MD, Baggett DW, Boden G. Branched-chain amino acid supplementation during bed rest: effect on recovery. J Appl Physiol. 2003 Apr;94(4):1345-52. Epub 202 Dec 06.

24) Tarnopolsky MA, Atkinson SA, MacDougall JD, Chesley A, Phillips S, Schwarcz HP. Evaluation of protein requirements for trained strength athletes. J Appl Physiol. 1992 Nov;73(5):1986-95.

25) Tipton KD, Ferrando AA, Phillips SM, Doyle D Jr, Wolfe RR. Postexercise net protein synthesis in human muscle from orally administered amino acids. Am J Physiol. 1999 Apr;276(4 Pt 1):E628-34.

26) Torigoe K, Potter PE, Katz DP. Branched-chain amino acid-induced hippocampal norepinephrine release is antagonized by picrotoxin: evidence for a central mode of action. Brain Res Bull. 1999 Jul 1;49(4):281-4.

27) van Hall G, Raaymakers JS, Saris WH, Wagenmakers AJ. Ingestion of branched-chain amino acids and tryptophan during sustained exercise in man: failure to affect performance. J Physiol. 1995 Aug 1;486 ( Pt 3):789-94.

28) Wagenmakers AJ. Amino acid supplements to improve athletic performance. Curr Opin Clin Nutr Metab Care. 1999 Nov;2(6):539-44.